ZETIA

ZETIA – Everything you wanted to know about it

ZETIA is an oral tablet prescribed along with a low cholesterol/ low-fat diet and exercise to help lower cholesterol in the blood. It is prescribed for patients who cannot control their cholesterol levels with the help of diet and exercise. Let’s get to know how it works, it’s uses, side effects, precautions to take care.

The drug can be given alone or with other drugs (such as “statins” or fibrates). This drug acts by reducing the amount of cholesterol your body absorbs from your diet. Lowering cholesterol levels in the body may help to prevent stroke and heart attack. The drug should be avoided in clients with moderate to severe liver disease. ZETIA drug has been approved in 2002 by FDA.

Read about other similar medications

ZETIA composition and active ingredients

ZETIA is available as an oral tablet containing 10 mg of ezetimibe as an active ingredient. ZETIA also contains following inactive ingredients:

  • Croscarmellose sodium NF
  • Lactose monohydrate NF
  • Magnesium stearate NF
  • Microcrystalline cellulose NF
  • Movidone USP
  • Sodium lauryl sulfate NF

How do ZETIA works?

ZETIA (ezetimibe) is a drug used to treat high cholesterol that works differently than statins, which lower cholesterol by 35 to 60% in most patients and reduce the risk of heart attack. Statins work by blocking an enzyme used by the liver to produce cholesterol.

The drug acts on the brush border of the small intestine and inhibits the absorption of cholesterol. This leads to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood; this distinct mechanism is complementary to that of HMG-CoA reductase inhibitors and of fenofibrate.

Dosage :

It is available as 10mg tablet usually prescribed once daily with or without food.

No dosage adjustment is  needed for mild to moderate liver or kidney impairment.

Concomitant Lipid-Lowering Therapy

ZETIA may be administered with a statin (in patients with primary hyperlipidaemia) or with fenofibrate (in patients with mixed hyperlipidaemia) for incremental effect. For convenience, the daily dose of ZETIA may be taken at the same time as the statin or fenofibrate, according to the dosing recommendations for the respective medications.

ZETIA uses and benefits

ZETIA (ezetimibe) is used in treatment for the following conditions:

  • Hypercholesterolemia
  • Hyperlipoproteinemia
  • Hypertriglyceridemia
  • Atherosclerosis
  • Myocardial infarction prophylaxis
  • Coronary artery disease prevention after a heart transplant
  • Stroke prophylaxis

Side effects of ZETIA

The listed side effects may not be the same in every individual. But if they persist take time for its cure, do consult your physician for immediate medical attention.

Below mentioned are some possible side effects of the use of ZETIA are, There may be other side effects too that are not mentioned here. Consult your physician for proper guidance before using this drug to avoid adverse side effects.

  • Pancreatitis
  • Muscular weakness
  • Chest pain
  • Dizziness
  • Headache
  • Diarrhoea
  • Cough
  • Mild stomach pain

Precautions before using ZETIA

Before you consume Zetia, inform your physician

  • If you are under any other medications, or using any over the counter products like supplements, herbal products, etc.
  • History of allergies, diseases, and also about your current health conditions, for eg; pregnancy, plan of surgery, etc.
  • About your health problems if any to avoid side effects.
  • The dose of this medicine should be strictly followed as directed by your physician or follow the directions printed on the product insert.

Pregnancy: This drug should be avoided during pregnancy unless the potential benefits outweigh the risk to the foetus. It should be taken only after consulting your physician and obstetrician as well.

Breastfeeding: This drug may be used only if the potential benefit justifies the potential risk to the nursing infant.

Overdosage

Taking more than prescribed ZETIA may cause harmful side effects. Consult your physician if you find any side effects. Read the label carefully before taking this medicine to avoid overdosage. An excess dose can result in confusion, dizziness, headache, fatigue, sedation.

Missing dosage

If you have missed a single dose, then take it as soon as possible, and if it’s near time for next dose, then skip the missed dose and continue the regular dosage schedule. Don’t take an extra dose.

 Drug Interactions

If your taking two or more different drugs together there is a chance of medicine interaction, resulting in adverse effects.

If you use other over the counter products or other drugs at the same time, the effects of the ZETIA may change. In such case, the risk of getting side effects might be higher or the effectiveness of the drug may impact. ZETIA may interact with the following medicines and products such as:

  • Colestipol
  • Cholestyramine
  • Gemfibrozil
  • Colesevelam
  • Cyclosporine
  • Blood thinners

Substitutes of ZETIA

Atorvastatin/ezetimibe combined drug- Lipitor

Rosuvastatin/ezetimibe combined drug- Crestor

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