Table of Contents

  1. What is Xarelto?
  2. Constituents of Xarelto tablet
  3. Indications/ Uses of Xarelto
  4. How does Xarelto work?
  5. Common Dosage of Xarelto
  6. When to Avoid Xarelto?
  7. Side effects of Xarelto
  8. Precautions to be observed while taking Xarelto
  9. Drug Interactions to be careful about
  10. Can I have Xarelto with alcohol?
  11. Can I have Xarelto When Pregnant?
  12. Can I have Xarelto when feeding a baby?
  13. Storage

What is Xarelto?

Xarelto is the brand name for Rivaroxaban which is an anticoagulant drug (blood thinner) that is used to prevent and treat the formation of blood clots. It is specifically used for the prevention and treatment of blood clots in deep vein thrombosis, pulmonary emboli, atrial fibrillation, coronary artery disease (CAD), peripheral artery disease (PAD) and following hip or knee surgery.

Get to know how Xarelto works, its uses, its side effects, precautions, and contraindications where the use of Xarelto is not suggested.

Constituents of Xarelto tablet

Xarelto is composed of an anticoagulant called as Rivaroxaban. It is available in the tablet form only for adults.

  • Manufactured by –Bayer Zydus Pharmaceuticals Private Limited
  • Prescription – Prescription is required
  • Form – Tablet
  • Type of Drug– Anticoagulant

Indications/ Uses of Xarelto

Xarelto is used for the prevention and treatment of the following diseases-

  • Prophylaxis for Deep Vein Thrombosis in hip or knee replacement surgery patients
  • Prophylaxia for Venous Thromboembolism in patients with restricted mobility
  • Non-valvular Atrial Fibrillation
  • Deep Vein Thrombosis
  • Pulmonary Embolism
  • Chronic coronary artery disease (CAD)
  • Peripheral artery disease (PAD)
  • Reduction of risk of major cardiovascular events like cardiovascular death, myocardial infarction, and stroke

How does Xarelto work?

The blood coagulation cascade is dependent on the activation of factor X to factor Xa via the intrinsic and extrinsic pathways, which play a central role in the blood clot formation.

Rivaroxaban inhibits both free and bound form of activated coagulation Factor X. Factor Xa is found bound in the prothrombinase complex. Xarelto is a highly selective direct inhibitor of factor Xa with a rapid onset of action. Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, thereby inhibiting thrombin formation as well as the development of thrombi.

Common Dosage of Xarelto

It is marketed in a variable dosage of 2.5mg, 10mg, 15mg, and 20mg as per requirement.

Consult your doctor for the proper recommendation based on your medical history, health, and possible drug interactions. The dosage will depend on the reason you are using this medication. The frequency and duration of treatment with Xarelto will be determined by your doctor based on your medical condition and response to treatment.

For some conditions, Xarelto should be taken with food. Follow your doctor’s dosing instructions very carefully. Do not increase or decrease your dose without consulting the doctor. Be punctual with the schedule and take the prescribed dose at the same time every day.

In case of a Missed Dose

If you are taking this medication once a day and by chance missed a dose, take it as soon as you remember. Skip the missed dose if it is time to the next dose. Take your next dose at the regular time. Do not take a double dose under any condition.

If you are taking this medication twice a day and missed a dose, take it as soon as you remember. If you missed the morning dose and it is near the time of the evening dose, you may take the total of both doses together. Then take your next dose at the regular time as prescribed.

In the case of Overdose

In case of an overdose, that is, consumption of an excessive amount of medication, take emergency healthcare consultation. The symptoms of overdose may include the presence of bloody/black or tarry stools; pink or dark-colored dark urine and; unusual or prolonged bleeding.

When to Avoid Xarelto?

Contraindications to the use of Xarelto include-

  • Hypersensitivity or allergy to the use of Rivaroxaban
  • Active pathological bleeding

You should also strictly avoid the use of Xarelto if you have any of the below-listed disease or symptoms-

  • A genetic spinal defect
  • A spinal catheter in place
  • History of spinal surgery or repeated spinal taps
  • Recent history of epidural anesthesia
  • A bleeding disorder 
  • Hemorrhagic stroke
  • Uncontrolled high blood pressure
  • Stomach or intestinal bleeding or ulcer
  • Patient suffering from Antiphospholipid syndrome – also called Hughes syndrome or sticky blood syndrome
  • An artificial heart valve
  • Liver disease.
  • Kidney disease
  • If you are taking NSAIDs like Advil, Motrin etc.
  • If you are using other medicines to treat or prevent blood clots.
  • If you are taking anti-depressants

Side effects of Xarelto

Apart from its intended benefits, Xarelto may cause some unwanted effects too. Few side effects are rare but they might be severe. If you observe any of the following side effects consult your doctor immediately and seek immediate medical attention.

  • Spontaneous bleeding is the most common side effect of Rivaroxaban.

 Other common side effects of Xarelto may include:

  • Muscle pain
  • Itching
  • Pain in your arms or legs
  • Unusual bruising
  • Prolonged bleeding from cuts or gums
  • Persistent or frequent nosebleeds
  • Unusually heavy or prolonged menstrual flow
  • Pink or dark urine
  • Blood in sputum or cough
  • Blood in vomit
  • Severe headache
  • Dizziness or fainting episode
  • Unusual or persistent weakness
  • Bloody/black or tarry stools
  • Difficulty in swallowing

If you observe any side effects from this medication, consult your doctor for medical advice. Take emergency consultation if you have any signs of very serious bleeding such as vision changes, confusion and slurred speech.

Precautions to be observed while taking Xarelto

  • Take Xarelto as prescribed by your doctor only.
  • Follow all directions on your prescription label and read instruction sheets.
  • Your doctor may occasionally change your dose. Use the medicine exactly as directed.
  • Tell any doctor you visit for treatment about your history of Rivaroxaban use.
  • If you need any medicine, surgery or dental treatment also, tell the consultant doctor ahead of time that you are using this medication. If you need anesthesia for a medical procedure or surgery, you may need to stop using this medicine for a short time.
  • Do not change your dose or stop taking this drug without taking consultation from your doctor. Stopping the intake of Rivaroxaban suddenly can increase your risk of a blood clot or stroke.

Drug Interactions to be careful about

If you are consuming other drugs or other over the counter products at the same time as Xarelto, the effects of the medications may change. This may increase the risk of side-effects. Inform your physician about all the drugs, vitamins, health boosters, and herbal supplements you are using, so that the physician can help you prevent or manage drug interactions effectively.

Xarelto most commonly interacts with the following medicines:

  • NSAID medications including Aspirin, Ibuprofen, Acetaminophen, Naproxen, Celecoxib, Diclofenac, Indomethacin, Meloxicam, etc.
  • Blood thinners including warfarin, Coumadin, Jantoven, etc.
  • Antidepressants including SSRIs such as fluoxetine and SNRIs such as Desvenlafaxine or venlafaxine
  • Erythromycin
  • Rifampin
  • St. John’s wort
  • Antifungal medication like itraconazole or ketoconazole
  • HIV medications like  indinavir, lopinavir, ritonavir
  • Seizure medications like carbamazepine, phenobarbital, phenytoin

This list is not comprehensive and hence other drugs may also interact with Rivaroxaban, including prescription drugs, over-the-counter medicines, vitamins, health supplements, and herbal products.

Can I have Xarelto with alcohol?

Consumption of alcohol while using this medicine will increase your risk of stomach bleeding. Limit the use of alcoholic beverages to avoid any serious complications. 

Can I have Xarelto When Pregnant?

Taking Xarelto may cause bleeding in the mother or the unborn baby if used during pregnancy. Tell your doctor if you are pregnant or are planning to get pregnant.

Can I have Xarelto when feeding a baby?

It may not be safe to breastfeed a baby while you are using this medicine. Xarelto can pass from milk to the baby. Ask your gynecologist about safe breastfeeding while taking Rivaroxaban.


  • Store at room temperature.
  • Store away from light, heat, and moisture.
  • Do not store in the bathroom.
  • Keep the drugs away from children and pets.


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