Table of Contents

  1. What is Vyvanse?
  2. Constituents
  3. Indications
  4. How does Vyvanse work?
  5. How to Take Vyvanse?
  6. Common Dosage for Vyvanse?
  7. When to Avoid Vyvanse?
  8. Side-effects of Vyvanse?
  9. Effects on organs?
  10. Reported Allergic Reactions?
  11. Effect of Vyvanse on the menstrual cycle?
  12. Drug Interactions To Be Careful About
  13. Food interactions
  14. Interactions with laboratory procedures
  15. Shows Effects / Results in (how long does the effect stay?)
  16. Is Vyvanse Addictive?
  17. Can I have Vyvanse with alcohol?
  18. Can I have Vyvanse When Pregnant?
  19. Can I have Vyvanse when feeding a baby?
  20. Can I drive after taking Vyvanse?
  21. Effect of an overdose of Vyvanse?
  22. Effect of using expired Vyvanse?
  23. Effect of missing a dose of Vyvanse?
  24. Storage requirements
  25. Substitutes for Vyvanse

What is Vyvanse?

Vyvanse is a CNS Stimulant medication prescribed to treat neurological conditions. This medicine is available in an orange-white capsule with an imprint of S489 on it in a pill identifier. Explore more details like uses, side effects, precautions, etc. about Vyvanse

Type of drug

Vyvanse is a CNS Stimulant medication. Vyvanse is categorized as Schedule II Drug or Controlled Substance in the United States as this medication has the high potentiality of drug abuse and can cause both psychological and physical damage to the patient if used over a long time.  

Use in brief

Vyvanse is prescribed to treat neurological conditions called Binge Eating Disorder and Attention Deficit Hyperactivity Disorder.


Lisdexamfetamine which is the prodrug of amphetamine is the key ingredient in this medication.

VYVANSE Capsules


Vyvanse is prescribed to treat medical conditions like –

  • Attention Deficit Hyperactivity Disorder (ADHD) – used to treat this condition in patients ages 6 years and above.
  • Binge Eating Disorder (BED) – used to treat these conditions when it is moderate to severe in adult patients.

How does Vyvanse work?

Lisdexamfetamine which is the key ingredient in this medication works by restoring the ideal balance of brain chemicals or neurotransmitters in the brain.

Read More: Combination CNS Stimulant medication – Diominic Dca

How to Take Vyvanse?

This medication comes in capsule and chewable tablet form.

  1. Capsule form is advised to take it as a whole with or without food.
  2. Chewable tablet form should be thoroughly chewed before swallowing.

When to use?

It is usually advised to take Vyvanse in the morning. Afternoon doses may cause insomnia. 

How to use

  • Advised to consume an entire capsule with some liquids or water.
  • Another advised method of consumption is to mix the entire contents in the capsule in some liquids like yogurt, orange juice or water.  Mix well until the medicine dissolves completely. Consume the entire mixture. Take it immediately after mixing. Never store after mixing.

Common Dosage for Vyvanse

If you are a cardiac patient or if there is a family history of cardiac problems, your doctor might suggest you undergo a few screening tests prior to treatment. Please make your doctor aware of any history of cardiac problems running in the family.

VYVANSE Capsules

It is available as 10mg, 20mg, 30mg, 40mg, 50mg, 60mg and 70mg capsules. 10mg, 20mg, 30mg, 40mg, 50mg, and 60mg chewable form tablets.

Vyvanse is usually prescribed to use once in a day and the dosage is decided by your doctor depending on the severity of the health condition treated.

Dosage of Vyvanse for treating Attention Deficit Hyperactivity Disorder (ADHD)

The recommended dosage for treating the ADHD is 30mg initially for patients from the age of 6 years and above and advised to take in the morning. Incremental dosage increases may be prescribed based on the response level.

Dosage of Vyvanse for treating moderate to severe Binge Eating Disorder (BED) in adults

The recommended dosage for treating Binge Eating Disorder in adults is 30mg initially. Incremental dosage increases may be prescribed based on the response level. Lisdexamfetamine dimesylate which is the key ingredient in Vyvanse was the first medication that got approval for the treatment of Binge Eating Disorder (BED) in adults from the United States Food and Drug Administration (US FDA). It got approval in the year 2015 on January 30th.

When to Avoid Vyvanse?

  • It should be avoided if you are under antidepressants like Monamine Oxidase Inhibitors for the past 14 days.
  • Also advised to avoid if you are allergic to other stimulant medications.

Side-effects of Vyvanse

Vyvanse may cause side effects in some patients. It is advised to consult the doctor if any of such side effects prolong. Side effects may not be the same for all the patients.

  • Decreased Appetite
  • Headache
  • Nausea
  • Upper Abdominal or Stomach Pain
  • Vomiting
  • Weight loss
  • Increase in heart rate and blood pressure.
  • Abuse and dependence.
  • Psychiatric adverse reactions may include- increase in the symptoms of pre-existing psychotic problems, symptoms of a manic episode in Bipolar disorder patients, new psychotic symptoms like hallucinations, delusions, etc.

Effects of Vyvanse on organs

Vyvanse may cause both physical damage to the organs and psychological issues if used for the long term or in case of drug abuse.

  • The major effect of this medicine may result in heart problems. Symptoms may include chest pain, a sudden change in heart rate, and sudden cardiac strokes. This risk of heart problems may be higher in patients with a history of cardiac issues in their family.
  • Psychological issues include general mood swings, convulsions, psychosis, and drug addiction.
  • Peripheral vasculopathy including Raynaud’s phenomenon: Circulation problems in fingers and toes. Please contact your doctor if you feel any new numbness, color change of skin, change in sensitivity to temperatures, any new wounds with unknown reasons on fingers and toes.
  • Suppression of growth in pediatric patients both weight and height.
  • Serotonin Syndrome: This is a life-threatening condition when Vyvanse is used in combination with other drugs like Monamine oxidase inhibitors, SSRIs, Tricyclic antidepressants, lithium, tramadol, St. John’s wort, etc. Symptoms of Serotonin Syndrome include digital ulceration and soft tissue breakdown.

Follow the dosage as mentioned in the prescription to avoid the side effects on organs and psychological issues.  

Warning: This drug should not be used for weight loss.

Reported Allergic Reactions?

Vyvanse may show some allergic reactions in a few cases which are very rare. It is advised to consult your doctor immediately if any such allergic reactions are noticed. Allergic reactions may be like

  • Hives
  • Difficult Breathing
  • Swelling in Face, Lips, Tongue, Throat

Effect of Vyvanse on the menstrual cycle

In general, Attention Deficit Hyperactivity Disorder (ADHD) may result in hormonal changes which may result in menstrual irregularities. Vyvanse can cause more cramping than normal during your periods. Please consult your gynecologist if you have any adverse effects on your menstrual cycles.

Drug Interactions to Be Careful About

Vyvanse is known to show drug interactions with the following medications and is advised to inform about your current medication list with your doctor before the prescription to avoid drug interaction complications.

  • Bupropion
  • Effexor (Venlafaxine)
  • Lexapro (Escitalopram)
  • Levothyroxine
  • Prozac (Fluoxetine)
  • Wellbutrin (Bupropion)
  • Wellbutrin XL (Bupropion)
  • Zoloft (Sertraline)

Food interactions

No significant food interaction is seen in the case of Vyvanse. Vyvanse can be used both with and without food. But certain foods that contain Vitamin C may lower the oral absorption of the medication. Hence it is advised not to eat citrus fruits at least 1 hour before and 1 hour after consuming the medicine.

Acidic foods like citrus fruit juices, cranberry juices may increase the renal excretion of the medicine and food items that may alkalinize the urine may slow down the renal excretion of the medicine. Some examples of such alkaline diets are beets, dairy products, kale, and spinach.

Interactions with laboratory procedures

Vyvanse may show interaction with some lab tests and alter the reports. Inform your doctor and lab specialist about your usage of Vyvanse before undergoing any lab test.

Shows Effects / Results in (how long does the effect stay?)

Lisdexamfetamine or Vyvanse may take approximately 1 hour to reach the peak concentration in plasma and the effect of the medication may stay till 13 hours after consumption.

Is Vyvanse Addictive?

Vyvanse is not known to cause drug abuse compared to the other medication used to treat ADHD. This medication is designed breakdown in the metabolic process very slowly. So there is no chance of getting a high from this medication. However, there is a chance of drug addiction as any mind-altering medication that works on CNS (Central Nervous System) may possibly have a chance of drug addiction. Hence this medication is classified as a prescription-only medication.

Can I have Vyvanse with alcohol?

Vyvanse is not advised to use along with alcohol as it is a CNS stimulant. This type of medication can minimize the effects of alcohol and as a result, you tend to drink more.

Can I have Vyvanse When Pregnant?

This medication is categorized under US FDA pregnancy category C. Medicines under this category are those which have studies conducted on animal reproduction in which adverse effects on the fetus are noticed, but where there are no proper studies conducted on the human reproductive system. Hence it is advised to consult your doctor if you have to use this medicine in pregnancy.  

Can I have Vyvanse when feeding a baby?

This medicine can be excreted into the mother’s milk and can pass to the infant. Hence this medicine is not advised for breast feeding mothers.

Can I drive after taking Vyvanse?

Vyvanse is a CNS stimulant medication and can affect the alertness of the brain. So it is not advised to drive or operate heavy machinery after consuming this medicine.

Effect of overdose Vyvanse

It is advised to stick to the prescribed dosage in the case of Vyvanse as the overdosage may result in drug abuse. Moreover, the overdosage may result in severe health problems that may need immediate critical care. Some symptoms of overdosage are –

  • Irregular Heartbeat
  • Rapid Breathing
  • Panic
  • Confusion
  • Vomiting
  • Hallucinations
  • Tremor
  • Hyperreflexia
  • Assaultiveness
  • Rhabdomyolysis

Effect of using expired Vyvanse?

Never use any expired medication. The usage of expired medication may not show the intended benefits and may cause undesired effects. Dispose of the expired medicine as per medical norms.

Effect of missing a dose of Vyvanse

There might be no major issue if one dose is missed. Try setting up a reminder to take the medicine regularly for the successful completion of the schedule.

Storage requirements

General storage requirements of the Vyvanse are-

  • Keep them at room temperature
  • Keep away from kids and pets
  • Keep away from direct sunlight

Substitutes for Vyvanse

Your doctor may prescribe any of the medication mentioned below as a substitute medicine to Vyvanse

  • Strattera (Atomoxetine is the key ingredient)
  • Ritalin (Methylphenidate is the key ingredient)
  • Focalin (Dexmethylphenidate is the key ingredient)

Details provided in this article are for informational purposes only and must not be considered as medical advice.


  1. https://en.wikipedia.org/wiki/Lisdexamfetamine
  2. https://www.healthline.com/health/adhd/vyvanse-effects-on-the-body
  3. https://www.additudemag.com/women-hormones-and-adhd/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978296/
  5. https://chadd.org/adhd-weekly/hormones-and-womens-adhd-symptoms-part-two/


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