What is PLIVA 433?

PLIVA 433 is an Antidepressant medication and belongs to the class of drug called Phenylpiperazine Antidepressants. It is used to treat conditions like depression, insomnia, fibromyalgia. This tablet has an imprint of its name on it as PLIVA 433. FDA has categorized this drug under Pregnancy Category C drug. Under the CSA (Controlled Substance Act). Get to know how PLIVA 433 works, its side effects, precautions, and contraindications where PLIVA 433 is not suggested.

PLIVA 433 composition

This medication contains the following drug as its key ingredient:

  • Trazodone 50 mg

Supplied by – Major Pharmaceuticals

Prescription – Required

Form – Tablet

Type of drug – Antidepressant medication

PLIVA 433 Uses

This is a prescription drug recommended to use for managing or reliving below mentioned medical conditions:

  • Depression
  • Insomnia
  • Anxiety
  • Improve Mood
  • To treat Major depressive disorder
  • Fibromyalgia
  • Sedation

How does PLIVA 433 work?

This drug works by restoring the normal levels of serotonin in the brain, which is involved in the mood swings in depressive patients.

Side Effects of PLIVA 433

When you use this drug there might be possibilities of getting some rare side effects too. Be aware of the side effects and if you suffer such issues and they don’t fade away soon, it is advised to consult your doctor for further diagnosis. Your doctor may make changes in dosage and treatment based on your condition. Below mentioned are few possible side effects of which some are common and few are critical. Consult your doctor immediately if you notice or suffer any of such serious side effects or any other symptoms even that are not mentioned here.

  • Nausea
  • Vomiting
  • Diarrhea
  • Drowsiness
  • Dizziness
  • Tiredness
  • Blurred vision
  • Changes in your weight
  • Headache
  • Muscle pains
  • Dry mouth
  • Bad taste in the mouth
  • Stuffy nose
  • Constipation
  • Change in sexual desire or/ and ability

Some Serious side effects may be like:

  • Tremors
  • Nightmares
  • Ringing in the ears
  • Problems urinating
  • Blood in urine
  • Fever
  • Sore throat
  • Shortness of breath
  • Stomach or abdominal pain
  • Chest pain
  • Fainting
  • Irregular heartbeat
  • Seizures
  • Eye pain or swelling redness
  • Widened pupils
  • Vision changes
  • Rashes
  • Severe dizziness
  • Trouble breathing

Precautions before Using PLIVA 433

As it is a prescription only drug it is highly recommended to follow the instruction by your doctor or read the label carefully before using this medication. It is advised to inform your doctor if you have any allergic reactions or any other general allergies to avoid any undesired side effects. Inform your doctor if you are using any other medication or any other over the counter drugs, health supplements, multivitamins, herbal medicine. It could help your doctor to make any modifications required in your medication. Based on your condition and severity your doctor may prescribe this medicine at a lower dose at the beginning, to make sure that medication is suitable for you. Inform your doctor if you have any of the following medical conditions:

A family history of any conditions like:

  • Bipolar disorder
  • Suicide attempts
  • Heart-related health issues
  • Liver disease
  • Kidney disease
  • Blood pressure problems
  • Glaucoma

Possible Drug interactions of PLIVA 433

While some drugs are used to treat certain medical conditions, there is a possibility of drug interactions if used along with some other medication which may result in adverse side effects too. It is recommended to share the information about any medication or supplements or any health products for proper diagnosis and treatment. Don’t make any changes in dosage without consulting your doctor. Below mentioned are few examples that PLIVA 433 has the possibility of showing drug interactions.

  • Abilify (Aripiprazole)
  • Adderall (Amphetamine / Dextroamphetamine)
  • Ambien (Zolpidem)
  • Amitriptyline
  • Ativan (Lorazepam)
  • Benadryl (Diphenhydramine)
  • Celexa (Citalopram)
  • Clonazepam
  • Cymbalta (Duloxetine)
  • Fish Oil (Omega-3 Polyunsaturated fatty acids)
  • Flexeril (Cyclobenzaprine)
  • Klonopin (Clonazepam)
  • Lamictal (Lamotrigine)
  • Lexapro (Escitalopram)
  • Lyrica (Pregabalin)
  • Melatonin
  • Nexium (Esomeprazole)
  • Norco (Acetaminophen/ Hydrocodone)
  • Oxycodone
  • Prozac (Fluoxetine)
  • Seroquel (Quetiapine)
  • Suboxone (Buprenorphine / Naloxone)
  • Synthroid (Levothyroxine)
  • Topamax (Topiramate)
  • Tylenol (Acetaminophen)
  • Vitamin B12 (Cyanocobalamin)
  • Vitamin D3 (Cholecalciferol)
  • Wellbutrin (Bupropion)
  • Xanax (Blprazolam)
  • Zoloft (Sertraline)

What is Pregnancy Category-C Drug?

According to the FDA, the drugs grouped under this section are those, which have shown an adverse effect on the fetus in animal studies, but there are no adequate and well-controlled studies in humans. It is not recommended in pregnancy unless strongly needed and the benefits outweigh risks involved.


  • It is advised to keep close monitoring of your pulse and the blood pressure.
  • This drug must be used in pregnancy only if the benefits overweigh the side effects.
  • Similarly in case of breastfeeding women also this medicine is recommended if strongly needed and the benefits overweigh the side effects.
  • If you missed a dose, it is advised to take it sooner possible, and if it is nearing the next dosage schedule, skip the missed dose and continue with regular dose.
  • Regular observation by your doctor is advised while using this medicine.

If for some reason an experienced doctor is not available around you, then you can contact us here.

Dr. Srishti Tayal is Chief Radiologist at Radiodent – Dental and Maxillofacial Imaging. She has completed BDS and MDS with Gold Medal from JSS Medical College, Mysore. She is a passionate medical researcher and has published five research papers in various medical journals and received an award for the best scientific paper.

In addition to following her pursuits in dentistry, she is also an avid medical writer who believes in bridging the information gap among the common population with regards to modern medicine.

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