Pazopanib Hydrochloride

Pazopanib Hydrochloride

What is Pazopanib Hydrochloride?

Pazopanib Hydrochloride is an anti-cancer medication prescribed to treat Advanced renal cell (kidney) cancer and advanced Soft tissue sarcoma (liposarcoma). This medication is prescribed to patients who are not responding to other alternated treatment options. Not recommended to use for patients younger than 18 years of age.

Type of drug:

Pazopanib Hydrochloride belongs to class of medicine called tyrosine kinase inhibitors. It is an anti-cancer medication.

Use in brief

Pazopanib Hydrochloride is prescribed to use in the treatment of soft tissue cancers and kidneys.

Constituents

Pazopanib Hydrochloride itself is an active ingredient in branded medicine well known as Votrient.

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Indications

Pazopanib Hydrochloride is prescribed in the treatment of below mentioned health conditions

  • Renal cell carcinoma (Kidney cancer)
  • Soft tissue sarcoma

How does Pazopanib Hydrochloride work?

Pazopanib Hydrochloride basically belongs to an anti-cancer type of drugs called tyrosine kinase inhibitors and works by stopping the multiplication of cancer cells by binding to the enzyme receptors. Also restricts the development of new blood vessels within the tumor that help to supply blood to the cancer cells.  

How to Take Pazopanib Hydrochloride?

Form of medicine – Pazopanib Hydrochloride medicine is available in the form of tablets 200mg and 400mg.

When and How to use

Follow the instructions about usage and timing as mentioned in the prescription. In general, this medicine is advised to use with an empty stomach.

Read about Lung cancer medications

Common Dosage:

The recommended starting dose is Pazopanib Hydrochloride 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal).it should not exceed more than  800mg. If a dose is missed, it should not be taken if it is less than 12 hours until the next dose. Follow the instructions by your doctor. Never take an extra dose if missed by mistake and if it is almost the next dosage scheduled time. Consult your doctor immediately for medical supervision if any overdosage happens.

When to Avoid Pazopanib Hydrochloride?

Pazopanib Hydrochloride is not advised to use in some health conditions such as:

  • Allergic reaction towards the Pazopanib Hydrochloride medication
  • In case of severe Hepatic impairment
  • Pregnancy
  • Breastfeeding
  • It should be avoided 7days prior to any surgery because it may impair wound healing capacity. Resuming its usage will be decided by your doctor after the wound heals adequately.
  • Not advised to use in patients aged below 18 years.

Advised to use with precautions and medical supervision in below mentioned health conditions

  • Cardiac disorders
  • Bleeding disorders
  • Kidney function impairment
  • Liver Disease
  • QT prolongation (a condition, where the heart muscles take longer time to get recharged between heartbeats)
  • Hypertension
  • Hypothyroidism
  • Lung dysfunction
  • Stomach or bowel problems

Side-effects of Pazopanib Hydrochloride

Pazopanib Hydrochloride may possibly show some side effects in some patients. It is advised to consult your doctor if any of such side effects are noticed and if they are prolonged. Below mentioned are some possible side effects by Pazopanib Hydrochloride. It may show side effects that are not mentioned here in this list.

  • Headache
  • Nausea
  • Vomiting
  • Musculoskeletal pain
  • Fatigue
  • Diarrhoea
  • High BP
  • Loss of appetite
  • Weight loss
  • Taste change
  • Abnormal skin pigmentation
  • Hair discoloration
  • Shortness of breath

Effects on organs

This medicine may possibly show adverse effects on organs like Liver, Kidney, and Heart.

  • No dose adjustment is required in the case of patients suffering with mild hepatic impairment. Alternatives to Pazopanib Hydrochloride should be considered in patients with moderate hepatic impairment. If Pazopanib Hydrochloride is used for patients with moderate hepatic impairment, the dose should be reduced to 200 mg per day. It is not recommended for patients with severe hepatic impairment.
  • Blood pressure should be well-controlled prior to initiating Pazopanib Hydrochloride. Hypertension occurs early in the course of treatment. Increased blood pressure should be treated promptly with standard anti-hypertensive therapy and dose reduction or interruption.

Serious infections (with or without neutropenia), including some with fatal outcome, have been reported.

It is advised to consult the doctor and share detailed information about the current health condition so that the doctor can alter the dosage depending on the patient’s health condition.

Reported Allergic Reactions?

It is not recommended in patients who have known allergic reactions towards Pazopanib Hydrochloride. Nausea, fatigue, diarrhoea are the commonly possible allergic reaction noticed.

Effect on menstrual cycle

This medicine may cause irregularity or stop the menstrual cycle temporarily. Consult your gynaecologist for further guidelines to follow.

Drug Interactions to Be Careful About

Pazopanib Hydrochloride may possibly show drug interaction with some other medication if they are used together. It is advised to share the medication details that you might be using any with your doctor before he prescribes this medicine to you.

Pazopanib Hydrochloride has the possibility of showing drug interaction if used along with the below-mentioned list of medicine.

  • Atazanavir
  • Ketaconazole
  • Ritonavir
  • Clarithromycin
  • Rifampicin
  • Adalimumab
  • Citalopram
  • Clozapine
  • Amiodarone
  • Cisapride
  • Sunitinib.

Food interactions

Consumption of grapefruit or grapefruit juice is not advised as this may affect the medicine levels in the blood and affect functioning of bone marrow which results in low WBC and platelet count.

Inform your doctor immediately if you feel any allergic symptoms such as paleness, dizziness, fatigue, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Follow the guidelines mentioned in the prescription as a safety precaution.

Interactions with laboratory procedures:

The following laboratory parameters have shown interactions with the usage of this drug.

Leukopenia, Lymphocytopenia, Thrombocytopenia, Neutropenia, increased AST, increased ALT, increased Glucose, decreased  Albumin, increased  Alkaline phosphatase, decreased Sodium, Total bilirubin increased, increased Potassium, increased Lipase.

Limited data is available on interaction with any diagnostic test while under the medication but it is always good to share details about your current medication before attending any lab tests so that your doctor and lab technician is aware of.

Is Pazopanib Hydrochloride Addictive?

No drug addiction is noticed in case of Pazopanib Hydrochloride.

Can I have Pazopanib Hydrochloride with alcohol?

Limited data is available about the effect of Pazopanib Hydrochloride if consumed with alcohol. Consult your doctor if you have a habit of taking alcohol on a regular basis.

Can I have Pazopanib Hydrochloride When Pregnant?

Not advised to use in general in pregnant women.

Can I have Pazopanib Hydrochloride when feeding a baby?

Not advised to use in general in breastfeeding women. It may cause adverse effects on the baby.

Can I drive after taking Pazopanib Hydrochloride?

Some patients may experience dizziness and blurred vision. Hence, it is not advised to do activities that require alertness such as ad driving or operating heavy machinery.   

Effect of overdose Pazopanib Hydrochloride

Serious adverse effects may be possible if overdosage happens in large quantities. Consult your doctor immediately in such situations.  

Effect of using expired Pazopanib Hydrochloride?

It is advised not to use any medicine that is expired to avoid adverse effects. Consult your doctor immediately if any adverse effects are noticed by taking any expired medicine. It is advised to check the label while purchasing the medicine to verify the expiry date to be safe.

Effect of missing a dose of Pazopanib Hydrochloride

No major adverse effects are noticed if only one dosage is missed. But if you are missing the dosages regularly, it is advised to keep a reminder so that you don’t miss the regular dosage.

Storage requirements

It is advised to store the medication away from direct sunlight, moisture, heat and to keep at room temperature. Keep away from the reach of the children and pets.

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Different Brands of Pazopanib Hydrochloride medicine available:

Below mentioned is the available brand of medicine that contains Pazopanib Hydrochloride.

  • Votrient 200mg Tablet, Votrient 400mg Tablet – Manufactured by Glaxo SmithKline Pharmaceuticals Ltd.

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