Palbociclib

Palbociclib

What is Palbociclib?

Palbociclib is a prescription medicine used to treat breast cancer. Generally, it is prescribed along with other medication or alone depending on the patient’s health condition. Your doctor may advise for frequent blood test to monitor blood cell count while under this medication. Palbociclib is not advised to use in patients below 18 years age group.

Type of drug

Palbociclib belongs to kinase inhibitors class of medication.

Use in brief

Palbociclib is prescribed in the treatment of breast cancer.

Constituents

Palbociclib itself is an active ingredient in different brands used to treat breast cancer.

Indications

Palbociclib is indicated for the treatment of HR-positive, HER2-negative advanced or metastatic breast cancer in combination with –

          1. an aromatase inhibitor as initial endocrine based therapy in postmenopausal women;

           2. fulvestrant in women (hormonal drug) with disease progression following endocrine therapy.

How does Palbociclib work?

Palbociclib belongs to the class of drugs called as kinase inhibitors. It works by blocking certain type of proteins that trigger the multiplication and growth of cancer cells.  

How to Take Palbociclib?

Form of medicine – Palbociclib medicine is available in the form of Capsules.

When and How to use

This medicine comes in Capsule form. Generally used after food. Never crush or chew the Capsule but swallow the whole medicine along with some water or liquids. In general this medicine is advised to use with food.

Common Dosage for Palbociclib

The recommended dose of Palpociclib is a 125 mg capsule taken orally once daily for 21 consecutive days followed by 7 days off treatment to comprise a complete cycle of 28 days. Palpociclib should be taken with food. The recommended dose of an aromatase inhibitor is administered along with Palpociclib.

Palpociclib (anti-cancer drug) is given along with fulvestrant 500mg (hormonal drug).

Your dosage is decided by the doctor. Follow the instructions by your doctor. Never miss a dose or take excess dose. Consult your doctor immediately if any excess dosage happens by mistake.

When to Avoid Palbociclib?

Palbociclib is not advised to use in patients suffering from some health conditions such as:

  • In patients who have allergic symptoms towards this medication
  • Women in breastfeeding stage
  • Women in pregnancy stage
  • In children below 18 years age group

Side-effects of Palbociclib

Palbociclib may possibly show some side effects in some patients. It is advised to consult your doctor immediately if any of such side effects are noticed. Below mentioned are some possible side effects by Palbociclib.

  • Diarrhoea
  • Nausea
  • Vomiting
  • Hair loss
  • Fatigue
  • Decrease in white blood cells and platelets
  • Anaemia
  • Decreased appetite
  • Infections
  • Chills and fever
  • Rashes

Effects on organs

Administration of Palbociclib has the possibility of causing Neutropenia (decrease WBC count) in some patients which may result in serious infections. Monitor complete blood counts prior to starting Palpociclib therapy and at the beginning of each cycle, as well as on Day 15 of the first 2 cycles, and as clinically indicated. Dose interruption, dose reduction, or delay in starting treatment cycles is recommended for patients who develop Grade 3 or 4 Neutropenia.

Consult your doctor immediately if symptoms like fever, chills or sore throat happen.  It is advised to consult the doctor and share detailed information about your current health condition so that the doctor can alter the dosage depending on your health condition.

Reported Allergic Reactions?

No major allergic reactions are noticed in case of Palpociclib. But it is not recommended in patients who have known allergic reactions towards Palbociclib.

Effect on menstrual cycle

Limited clinical data is available regarding the effect of this medicine on menstrual cycle. You may consult your gynaecologist.

Drug Interactions to Be Careful About

Palbociclib may possibly show drug interaction with some other medication if they are used together. It is advised to share the medication details that you might be using any with your doctor before he prescribes this medicine to you.

Some of the drugs with which Palbociclib shows interaction include:

  • Phenobarbital
  • Adalimumab
  • Carbamazepine
  • Clarithromycin
  • Live-attenuated vaccines
  •  alfentanil, Cyclosporine, Dihydroergotamine, Ergotamine, Everolimus, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus

Food interactions

Consumption of grapefruit or grapefruit juice is not advised as this may affect the medicine levels in the blood and cause severe side effects such as nausea, vomiting, loss of appetite, mouth sores, diarrhoea, hair loss, pain, numbness, weakness. Follow the guidelines mentioned in the prescription as a safety precaution.

Interactions with laboratory procedures

Limited data is available about the interaction of Palbociclib with laboratory procedures, but it is always good to share details about your current medication before attending any lab tests so that you doctor and lab technician is aware of.

Is Palbociclib Addictive?

No drug addiction is noticed in the case of Palbociclib.

Can I have Palbociclib with alcohol?

Limited data is available regarding the interaction of this medicine with alcohol. Consult with your doctor if you have a habit of regular intake of alcohol.

Can I have Palbociclib When Pregnant?

Not advised to use in general in pregnant women. But with consultation and supervision in case if unavoidable and the intended benefits are more compared to possible side effects.

Can I have Palbociclib when feeding a baby?

Not advised to use in general in breastfeeding women. But with consultation and supervision in case if unavoidable and the intended benefits are more compared to possible side effects.

Can I drive after taking Palbociclib?

Palbociclib may cause general weakness as a side effect in some patients. In such conditions, it is not advised to do activities such as driving which require alertness.

Effect of overdose Palbociclib

Serious adverse effects may be possible if over dosage happens in large quantities. Consult your doctor immediately in such situations.

Effect of using expired Palbociclib?

It is advised not to use any medicine that is expired to avoid any adverse effects. Consult your doctor immediately if any adverse effects are noticed by taking any expired medicine. It is advised to check the label while purchasing the medicine to verify the expiry date to be safe.

Effect of missing a dose of Palbociclib

No major adverse effects are noticed if only one dosage is missed. But if you are missing the dosages regularly, it is advised to keep a reminder so that you don’t miss the regular dosage.

Storage requirements for Palbociclib

Storage of this medicine requires refrigeration and away from direct sunlight. Keep away from the reach of the children and pets.

Available brands of Palbociclib

Below mentioned is the available brand of medicine that contains Palbociclib as key ingredient, and your doctor may prescribe this to treat the condition.

  • Palbace 125 mg Capsule  – manufactured by Pfizer Ltd.
  • Ibrance 125mg Capsule   -manufactured by Pfizer Ltd.

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