Ofloxacin uses and precautions


Ofloxacin belongs to a class of drugs called quinolone antibiotics. This medication is used to treat a variety of bacterial infections. Get to know how Ofloxacin works, its side effects, precautions, and contraindications where Ofloxacin is not suggested.

About Ofloxacin

Ofloxacin works by killing the bacteria which are the cause of the infection. This antibiotic treats only bacterial infections. It will not work for viral infections (such as flu & common cold). It is useful for treating infections such as urine infections, chest infections, skin and soft tissue infections, and some STD’s (sexually transmitted infections). Some infections can be treated with a single tablet; others require a course of treatment lasting a week or so.

Consider reading about some similar medications:

How does Ofloxacin work?

Ofloxacin belongs to a class of medications called quinolone antibiotics. A class of drugs is a group of medications that work in a similar way. These medicines are often used to treat similar conditions.

Ofloxacin works by killing the bacteria that are causing an infection by inhibiting the DNA replication. You should only use this medication to treat bacterial infections.

Ofloxacin Uses and benefits

Ofloxacin is used to treat bacterial infections in adults and also to control, prevention, & improvement of the following diseases, conditions, and symptoms:


Ofloxacin is used in the treatment of community-acquired pneumonia which is a most common type of lung infection caused by Haemophilus influenzae and Streptococcus pneumoniae.


Ofloxacin used in the treatment of Nongonococcal urethritis which is an inflammation of urethra caused by E.coli, Pseudomonas aeruginosa, and Klebsiella.


Ofloxacin used in the treatment of bronchitis which is an inflammation in lungs caused by Haemophilus influenzae, Streptococcus pneumoniae, and some Mycoplasma pneumoniae.

Traveler’s Diarrhea

Ofloxacin used in the treatment of Traveler’s Diarrhea which is caused Enterotoxigenic Escherichia coli (ETEC) bacteria.


Ofloxacin is used in the treatment of cystitis which is a bladder infection caused by Pseudomonas aeruginosa, Enterococci E.coli, and Klebsiella pneumoniae.

Salmonella Enteric Fever

Ofloxacin is used to treat of salmonella enteric fever which is caused by Salmonella typhi.


Ofloxacin used in the treatment of Pyelonephritis which is a type of kidney infection caused by E.coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterococci.

Skin and Structure Infection

Ofloxacin is used in the treatment of Skin and Structure infection like cellulitis, wound infection and cutaneous abscess caused by Staphylococcus aureus and Streptococcus pyogenes.

Infections of urethra and cervix

Ofloxacin is used to treat mixed Infections of the urethra and cervix which are caused by Neisseria gonorrhoeae and Chlamydia trachomatis.


Ofloxacin is used in the treat Shigellosis which is caused by bacteria called Shigella.

Ofloxacin side effects

In addition to its intended benefits, Ofloxacin may cause some unwanted effects too. In such cases, you must seek medical attention immediately. Please inform your physician if you notice any adverse reaction to the medication.  Check with your physician immediately if any of the following side effects occur while taking Ofloxacin:

  • Upset stomach
  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Light-headedness or trouble sleeping

If any of these effects persist or worsen, tell your physician promptly. Remember that your physician has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects.

Tell your physician right away if you have any serious side effects, including:

  • Signs of a new infection (such as fever, persistent sore throat)
  • Signs of kidney problems (such as change in the amount of urine)
  • Easy bruising and bleeding
  • Signs of liver problems (such as unusual tiredness, stomach pain, persistent vomiting and nausea, yellowing eyes or skin, dark urine)

Contraindications for Ofloxacin

Ofloxacin contraindicated in following conditions:


This drug is not recommended for use if you have a known allergy to Ofloxacin or any other quinolones.

Myasthenia gravis

Ofloxacin is not recommended for use if you have a past history of myasthenia gravis or family history of myasthenia gravis (weakness and rapid tiring of muscles which are under voluntary control).

Tendon rupture or Tendinitis

This drug is not recommended for use if you have a past history of tendinitis or tendon rupture after using Ofloxacin or any other quinolones.

Precautions while taking Ofloxacin

  • Never take antibiotic medicines for a viral infection like a cold or the flu.
  • Always take the complete course of treatment, as advised by your physician even if you feel better.
  • If you notice any side effects; stop taking Ofloxacin immediately and consult your physician.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Inform your doctor if you have ever been diagnosed with kidney, epilepsy or heart diseases.
  • Before taking Ofloxacin, tell your physician if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your physician for more information.
  • Before using this Ofloxacin, tell your physician your medical history, especially of: severe kidney problems, have a history of tendon problems (eg, rheumatoid arthritis), or have received an organ (example; kidney, heart, or lung) transplant.
  • Before having this medicine, tell your physician about all the products you use (including herbal products, prescription drugs, and non-prescription drugs).
  • During pregnancy, Ofloxacin should be used only when clearly needed. Discuss the benefits and risks with your physician.
  • It is unknown if Ofloxacin passes into breast milk. Discuss the risks and benefits with your physician before breastfeeding.

Ofloxacin dosage

Should be used exactly as directed by your physician. The usual dosage is described below:

You should take your Ofloxacin tablets swallowed whole with a glass of water and with food, take this medicine depending on your condition and your physician’s recommendation.  You should avoid taking this drug while drinking alcohol, as you may experience some unpleasant effects, including vomiting, nausea, stomach cramps, headache, and fast heartbeat.  You should complete the course of Ofloxacin, which is usually for 6-10 days, even if you are feeling better or the infection may not clear up completely.

Ofloxacin – Drug Interactions

If you use other over the counter products or other drugs at the same time, the effects of the Ofloxacin Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your physician about all the drugs, vitamins, and herbal supplements you are using, so that your physician can help you prevent or manage drug interactions. This medicine may interact with the following medicines and products:

  • Antacids
  • Sucralfate
  • Metal Cations
  • Multivitamins
  • Caffeine
  • Cimetidine
  • Cyclosporine
  • Drugs metabolized by Cytochrome P450 enzymes
  • Non-steroidal anti-inflammatory drugs
  • Theophylline
  • Warfarin
  • Antidiabetic Agents (e.g., insulin, glyburide/glibenclamide)
  • Alcohol

Substitutes for Ofloxacin

Below is the list of medicines, which have the same composition, strength, and form as Ofloxacin and hence can be used as its substitute:

  • Floxin (Rx)
  • Ciprofloxacin (Rx)
  • Metronidazole (Rx)
  • Levofloxacin (Rx)
  • Cipro (Rx)
  • Azithromycin (Rx)
  • Doxycycline (Rx)
  • Amoxicillin (Rx)
  • Levaquin (Rx)

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