Lisinopril is categorized as an angiotensin converting enzyme (ACE) inhibitor group of drug. It is frequently prescribed in patients with hypertension and heart failure. Get to know how Lisinopril works, its side effects, precautions, and contraindications where Lisinopril is not suggested.
In addition, this drug may be prescribed in patients with a recent history of heart attack or for those suffering from diabetic kidney disease. This drug is essentially a peptidyl dipeptidase inhibitor. This drug assists in vasodilatation by preventing the conversion of angiotensin I to angiotensin II. That is, this drug widens the diameter of blood vessels and hence, assists in lowering blood pressure. Lisinopril is an ACE (angiotensin-converting enzyme) inhibitor used in the treatment of hypertension, myocardial infarction (heart attack), congestive heart failure, and stroke.
This drug is available under various brand names in India and is marketed by major pharmaceutical companies, such as GlaxoSmithKline and Sanofi, to name a few.
Few Brand names of Lisinopril in India:
How does Lisinopril work?
Lisinopril is an ACE (angiotensin-converting enzyme) inhibitor. It works by reducing stress on the heart and relaxing arteries and blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently.
It is used to treat an increase in the blood pressure caused by genetic and/or environmental factors.
Congestive Heart Failure (CHF)
Lisinopril is used in the treatment of congestive heart failure (CHF) which is a type of heart disease, characterized by thickening of the walls of the left ventricle.
It is used in the treatment of myocardial infarction which is a type of heart disease, characterized by blocking off blood vessel that pumps blood to the heart.
Lisinopril side effects
Side effects reported with this drug are rather rare. Nonetheless, it is important to know what they may cause. The common side effects of Lisinopril are:
- Decreased urine output
- Blurred vision
- Chest discomfort
- Skin Rash
- Acid or sour stomach
- Abdominal Pain
- Fast heartbeat
- Joint Pain
- Lack of strength
It is always advisable to report even minor side effects to your doctor. In case major or persistent side effects, the doctor may change your medication or may prescribe a more suitable dose.
In general Lisinopril is not prescribed in pregnancy nor in lactating mothers. However, the drug may be prescribed if the physician considers that the benefits of the medicine outweigh the risks. Mid proportions of this drug have been found in human breast milk.
Lisinopril should be taken in specific doses as prescribed by the physician. It is likely that your doctor may assess your blood pressure before prescribing the drug. He may also give some additional instructions; which must be followed.
Most physicians prescribe a low dose of Lisinopril, initially, to prevent their patients from experiencing a sudden sense of dizziness after their first dose. This measure also helps in an early detection of any allergic reaction to the medication.
If the patient tolerates the medicine well; that if no adverse events are reported, the doctor may gradually increase the dose if necessary.
It is advisable not to miss any dose of this drug; however, in case a pill is missed, it can be taken at a later part of the day. But if the dose is missed, it can surely not be added on to your next day’s dose.
Dosage for hypertension
Starting dose: 10 mg (milligram) taken by mouth once per day
Usual dose: 20–40 mg (milligram) taken once per day
Dosage for heart failure
Starting dose: 5 mg (milligram) taken by mouth once per day
Maximum dose: 40 mg (milligram) taken once per day
Dosage for acute myocardial infarction (heart attack)
Usual dose: 10 mg (milligram) given 48 hours after heart attack.
Contraindications for Lisinopril
Although Lisinopril can be safely prescribed to adults and children aged above 6 years, caution should be practiced to prevent unscrupulous prescriptions. Intake of this drug should be avoided in:
- Liver disease
- Unstable or low blood pressure
- Diarrhea or vomiting
- Low white blood cell count
- In patients who are on low salt diet
And in those who are scheduled for a major surgery in the near future.
Expert advice for Lisinopril
- While using Lisinopril You may get a dry cough. Report or consult your doctor if there is a persistent cough.
- Avoid taking potassium supplements and potassium-rich foods such as broccoli and banana, Lisinopril may cause the level of potassium in blood to go up.
- Consult your doctor immediately if you have rapid swelling of the lips, tongue, and throat that may affect breathing.
- Inform your doctor if you have ever been diagnosed with liver or kidney problems.
- You should not take Lisinopril if you’re pregnant or plan to become pregnant. This medicine may cause birth defects or be fatal to your unborn baby.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Warnings and precautions while using Lisinopril
Lisinopril is not recommended for pregnant women.
Lisinopril is not recommended for women who are breastfeeding.
Black box warnings
Stop taking Lisinopril as soon as pregnancy is detected as it may affect renin-angiotensin system can cause injury and death to the developing fetus.
Impaired liver function
This medicine may rarely cause liver injuries like jaundice or hepatitis. Stop taking Lisinopril if any signs of liver injury like increased liver enzyme levels.
In case, too many of Lisinopril tablets have been consumed, rushing to a nearby hospital and seeking help is prudent. If possible, it is also advisable to contact the doctor and ask for advice.
Overdose of this drug may cause dizziness, sleepiness, and a pounding heartbeat.
If you miss the dosage take as soon as possible, and if it is near to next dose, skip the missing dosage continue the regular dosage. Do not take extra doses.
Similar to most medicines, Lisinopril interacts with certain drugs. Hence, if you are taking any of the following medications, you must bring them to your physician’s knowledge before taking Lisinopril.
- Anti-inflammatory drugs, for instance, ibuprofen and aspirin.
- Antihypotensives, such as ephedrine, noradrenaline or adrenaline
- Antihypertensive, such as aliskeren
- Certain antidepressants, nitrates, baclofen, anesthetics.
- Immunosupressants, for example – ciclosporin or tacrolimus
- Spironolactone, triamterene, amiloride, potassium supplements
- Blood thinners, like Heparin
- Steroids, such as Prednisolone
Alternative medicines to Lisinopril
Here is the List of substitute’s medicines which have the same composition, strength, and form as Lisinopril:
- Zestril (Lisinopril)
- Lotensin (benazepril)
- Capoten (Captopril)
If for some reason an experienced doctor is not available around you, then you can contact us here.
Dr. Kaleem Mohammed graduated as a Bachelor of Physiotherapy in 2014 from Deccan College of Physiotherapy, affiliated to Dr. N.T.R. University of Health Sciences, Vijayawada, India. Dr. Kaleem is an expert at handling physiotherapy needs of patients suffering from orthopedic and spinal conditions and post-surgery rehabilitation. Dr. Kaleem is associated with HealthClues since its inception where he facilitates diagnosis and advanced consultation with senior doctors. He is also a medical researcher and prolific writer who loves sharing insightful commentaries and useful tips to educate the patient community about fitness, treatment options, and post-treatment recovery.