Duphaston 10mg Tablet is a prescription medicine used for treating conditions like Female infertility, Pain during menstruation, Endometriosis and also used as a part of hormonal replacement therapy. Get to know how Duphaston works, its side effects, precautions, and contraindications where Duphaston is not recommended.

Read about Duphaston in Hindi

Composition of Duphaston

Dydrogesterone (10mg), synthetic hormone progesterone is the key ingredient in this medicine. This medicine is available in tablet form.
Manufactured By – Abbott India Limited
Prescription – Required
Form – Tablets
Type of Drug – Synthetic hormonal medicine

How does Duphaston work?

The mechanism of action of Duphaston tablet is by reducing the growth of the endometrium. Dihydrogesterone is a synthetic derivative of hormone progesterone. Naturally, hormone progesterone acts on lining of uterus called endometrium. If conception occurs, it stops growth of endometrium and starts the secretion of hormones and other protein required to maintain a pregnancy. If not, levels of oestrogen hormone and hormone progesterone will reduce and the endometrium is shred (menstruation)

Lack of endogenous hormone progesterone causes menstrual disorders or menstrual irregularities such as secondary amenorrhea and abnormal uterine bleeding. In such conditions, Duphaston helps reestablish a regular menstrual cycle. Duphaston helps in the treatment of infertility, risk of miscarriage and habitual abortion by stimulating the endometrium to prepare for a pregnancy and protect an existing pregnancy

Duphaston acts on the endometrium in all its locations to stop the growth thereby reducing symptoms of endometriosis including pain and bleeding.

Duphaston Uses and benefits

This drug is prescribed for the treatment of conditions resulting from lack of naturally produced progesterone such as:

  • Pain during menstruation
  • Infertility in women
  • Abnormal uterine bleeding
  • Pre-menstrual syndrome
  • Endometriosis – this is a condition in which the inner lining tissue of the uterus called endometrium grows outwards. This drug is prescribed to control the growth of the endometrium.
  • Amenorrhea – the condition of absence of menstruation for one or more times in a row.
  • Hormone replacement therapy

Duphaston side effects

In addition to its intended benefits, Duphaston may cause some side effects too. In such cases, you must seek medical attention immediately. Please inform your physician if you notice any kind of adverse reaction while using this medication. Check with your doctor immediately if any of the following side effects occur while taking Duphaston:

  • Nausea
  • Weight gain
  • Skin rash and itching
  • bloating
  • Edema
  • Anxiety
  • Pulsating headache
  • Abdominal discomfort
  • Irregular bleeding
  • Irritability
  • Depression
  • Muscle pain

Contraindications for Duphaston

This drug is not prescribed in the conditions mentioned below. Let your doctor know if you are suffering from any kind of health problems mentioned below.

  • Hypersensitivity – allergic to Dydrogesterone or any other ingredient in Duphaston
  • Severe vaginal bleeding
  • Stroke
  • Incomplete abortion
  • Family history or past history of Breast cancer, endometrial carcinoma
  • Brain cancer
  • History of liver diseases
  • If you are in the final or third trimester of your pregnancy

Precautions while taking Duphaston

Some medications are not suitable for people with certain ailments, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using this medicine, it is important to inform your doctor if you are suffering from any of the following conditions:

  • Any abnormal bleeding
  • Breast cancer
  • Cancer of the uterus lining
  • Depression
  • Use of Estrogen-related medicine
  • Porphyria
  • Pregnant or planning to become pregnant

Duphaston 10mg Tablets Dosage

Take Duphaston 10 mg tablets once or twice daily with or without food. The dosage depends on your condition being treated. Take this drug in the dose and duration as prescribed by your doctor


Taking more than prescribed dosage may cause harmful side effects. Consult your doctor or pharmacist if you find any side effects.

Missing dosage

If you miss the dosage, take as soon as possible, and if it is near to next dose, skip the missing dosage and continue with the regular dosage. Do not take extra doses.

Pregnancy and Breastfeeding

It is recommended to use this medication with proper prescription and advice from your gynecologist.

Duphaston – Drug Interactions

If you use other over the counter products or other drugs at the same time, the effects of the drug may change and may increase your risk for side-effects or cause your drug not to work properly. Tell your physician about all the drugs, vitamins, and herbal supplements you are using, so that your physician can help you prevent or manage drug interactions. This medicine may interact with the following medicines and products:

  • Carbamazepine
  • Griseofulvin
  • Phenobarbital
  • Rifampicin

Substitutes for Duphaston 10mg Tablets

Below is the list of medicines with similar composition, strength, and form as Duphaston 10mg Tablets and hence can be used as its substitute:

  • Jigest 10mg Tablet – Sanzyme Ltd
  • Gestasure Capsules – Mankind Pharmaceuticals Pvt Ltd

If for some reason an experienced doctor is not available around you, then you can contact us here.


    0.0 rating based on 12,345 ratings
    Overall rating: 0 out of 5 based on 0 reviews.
    Review Title
    Review Content






    Leave a Reply

    Your email address will not be published. Required fields are marked *