Dolo 650 – Composition, Uses, Side-Effects, Substitutes, Warnings

Dolo 650 is a Paracetamol tablet which is commonly prescribed to attenuate fever and for relieving pain, such as muscle ache, headache, joints pain, toothache, ear pain and menstrual pain. Get to know how Dolo 650 works, its undesirable effects, precautions, and contraindications where Dolo 650 is not suggested.

Read about DOLO 650 in Hindi


Dolo 650 is a brand name of oral tablets, most commonly used over the counter medicine available in all pharmacies generally used for pain relief and fever. It is manufactured and marketed by Micro Labs Ltd. These tablets are packaged as 15 units in each strip. Dolo 650 tablet is a Paracetamol (also known as acetaminophen).


Although the drug is easily available over-the-counter in India and in several other developing nations, it should be taken only on a doctor’s or a healthcare professional’s recommendation.
Moreover, the disadvantage of using a drug without supervision is that one may not know whether a particular drug would cause an adverse effect or whether the dosage would be accurate. Different individuals may require variable doses of the same medication. Additionally, long time use of certain drugs, for instance, Dolo, without consulting a doctor can be very harmful.

1. How does it work?
2. Uses of Dolo 650 MG Tablet
3. Contraindications for Dolo 650 Tablet
4. Side effects of Dolo 650 Tablet
5. Doctor’s advice for DOLO 650 Tablet
6. Dolo 650 Tablet – Precautions & How to Use
7. Substitute tablets for Dolo 650

How does Dolo 650 work?

Dolo 650 tablets contain Paracetamol as its primary component. Paracetamol produces dual action, namely, as a fever reducer (antipyretic) and as a painkiller (analgesic).
Paracetamol acts as an antipyretic by inhibiting the synthesis of prostaglandins (PGs) – a mediator of inflammation, and by decreasing their concentration. Its analgesic action is expressed through the inhibition of cyclooxygenase-1 (COX-1) and COX-2 cascading pathways. Although the primary site of action of Paracetamol is PGs, the analgesic effect of Paracetamol is via the central nervous system and is expressed due to the activation of descending serotonergic pathways by this drug.

 Read More About :- Paracetamol 

When administered orally, this tablet is rapidly absorbed from the gastrointestinal tract. The onset of action of this drug commences one hour after its intake. It is advised to maintain a minimum of 6 hourly gaps between consecutive doses of this drug.
Dolo is extensively and predominantly metabolized in the liver. In healthy individuals, 85-95 percent of this drug is excreted through urine within 24 hours of administration.
This medicine takes half an hour to 1 hour to start its action, which lasts for 6 hours.

Uses of Dolo 650 MG Tablet:

Dolo 650 Tablet is prescribed for treating the below-mentioned conditions, diseases, and symptoms:

Tynor Hot and Cold Pack

 Read More About :- Joint pain – how an early intervention helps? 

Contraindications for Dolo 650 Tablet:

Dolo 650 tablet is contraindicated or cannot be prescribed if you are suffering from following conditions:

  • Allergy to any of the components of Dolo
  • Liver Disease
  • Analgesic Nephropathy (Kidney Disease)
  • Chronic alcoholism

Side effects of Dolo 650 Tablet:

During the intake of this Dolo tablet, below mentioned side effects are possible but do not always occur. An immediate consultation with your doctor is advised if you suffer any such adverse side effects that last for a long time, and may make you uncomfortable.

  • Skin reddening
  • Allergic reactions
  • Shortness of breath
  • Feeling of sickness
  • Rashes
  • Liver damage
  • Gastric / Mouth Ulcer
  • Anemia
  • Runny nose
  • Nausea
Kindly note, this is not a comprehensive list of the adverse effects that may be caused by this drug.

Drug Interactions:

Dolo 650 when used along with any of the following drugs can cause increased side effects

  • Carbamazepine
  • Sodium Nitrite
  • Phenytoin
  • Isoniazid
  • Naltrexone
  • Prilocaine
  • Leflunomide
  • Juxtapid mipomersen
  • Teriflunomide
  • Ketoconazole

Doctor’s advice for Dolo 650 Tablet:

Dolo is a safe and well-tolerated medicine for short-term use. However, consuming high doses of Dolo can cause serious liver damage. If you are suffering from liver disease, inform your doctor during your first consultation and before you are prescribed any medications. The doctor will then decide upon an alternative medicine or whether you require an adjusted dose of the same medicine.

Intake of alcohol in excessive quantities should be completely restricted while on this drug since the combination of Dolo and alcohol result in serious damage to the liver.

Dolo 650 Tablet – Precautions & How to Use:

It is always recommended to inform your physician about your current list of medications, the use of over the counter products (for example, vitamins, herbal supplements), as well as known allergies, pre-existing diseases, and current health condition. Furthermore, you must also make sure that your doctor is aware of your current health status, for instance, pregnancy, recent or upcoming surgery or a recent episode of illness. This is because some health conditions may make you more susceptible to the side-effects of certain drugs. This is also applicable to Dolo tablet.

The following precautions should be practiced when on Dolo tablet:

  • Avoid taking Dolo tablet with alcohol since this can increase the risk of stomach bleeding.
  • Dolo 650 tablet does not harm the foetus, but it is advisable to consult your doctor before taking this drug during pregnancy.
  • Dolo 650 tablet is safe to use during lactation, yet, it is important to consult your doctor.
  • Dolo 650 tablet should be used with caution in patients with liver disease.
  • Dolo 650 should be used with caution in patients with renal diseases. The doctor may suggest dose adjustment before prescribing Dolo in such patients.
  • Do not use other tablets to substitute Dolo, unless such a change in medication is indicated by a physician.


Intake of the unregulated amount of Dolo tablet or having more than the prescribed dose may cause harmful side effects. In case of an overdose or adverse reaction, a doctor or a healthcare professional, such as a nurse or pharmacists should be informed immediately, so that the patient receives first aid before he or she can be reached to the hospital.

Missing dosage:

Very often Dolo may not be prescribed as a regular course, but may be indicated only as and when required; such as in mild pain or intermittent fever. Therefore some patients may possibly forget to take the tablet on time.

In case you miss a dose of Dolo, it is recommended to take it as soon as you remember. However, if you remember only when it’s about time for the next dose, it is better to skip the missed dose. Also, caution should be exercised to not take extra doses, even by mistake.

Substitute tablets for Dolo 650:

Below is the list of medicines, which have the same active ingredients, strength, and form as Dolo 650 MG tablet.

  • Paarmol 650 MG Tablet
  • Glenpar 650 MG Tablet
  • P U C 650 MG Tablet
  • T98 650 MG Tablet
  • Welset 650 MG Tablet

If for some reason an experienced doctor is not available around you, then you can contact us here.


Dolo 650 - Composition, Uses, Side-Effects, Substitutes, Warnings
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found very good information. thanks!
- Roshan
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