Dasatinib

Dasatinib

What is Dasatinib?

Dasatinib is a prescription medicine used to treat a type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) that occurs due to abnormality in chromosomes. This medicine is also prescribed in treating WBC (White Blood Cells) cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Lymphoblastic leukemiaorWBC cancer occurs when the bone marrow produces immature and cancerous lymphoblasts in large quantities.

Type of drug

Dasatinib belongs to kinase inhibitors class of medication.

Use in brief

Dasatinib is prescribed in the treatment of blood cancer and WBC cancer.

Constituents

Dasatinib itself is an active ingredient in different brands used to treat blood cancer.

Indications

Dasatinib is indicated for:

  • Newly diagnosed adults with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase.
  • Treatment of chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including imatinib.
  • Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) with resistance or intolerance to prior therapy.

How does Dasatinib work?

Dasatinib belongs to the class of drugs called as kinase inhibitors. It works by blocking certain type of proteins that trigger the multiplication and growth of cancer cells.  

How to Take Dasatinib?

Form of medicine – Dasatinib medicine is available in the form of tablets.

When and How to use

This medicine comes in tablet form. Generally used after food. Never crush or chew the tablet but swallow the whole medicine along with some water or liquids. In general this medicine is advised to use with food.

Common Dosage for Dasatinib:

It is available as tablet 20mg, 50mg,70mg, 80mg, 100mg, 140mg.

The recommended starting dosage of Dasatinib for chronic phase CML is 100 mg administered orally once daily. The recommended starting dosage of Dasatinib for accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL is 140 mg administered orally once daily.

However dosage depends on the severity of the cancer been treated and is decided by the doctor. Follow the instruction by your doctor. Never miss a dose or take excess dose. Consult your doctor immediately if any excess dosage happens by mistake.

When to Avoid Dasatinib?

Dasatinib is not advised to use in patients such as:

  • In patients who have allergic symptoms towards this medication
  • Women in breastfeeding stage
  • are pregnant or planning to become pregnant

Usage with caution

If Dasatinib is advised to use with caution in patients suffering from some health conditions such as –

  • Gastrointestinal disorders
  • Thrombocytopenia
  • Agranulocytosis
  • Anemia
  • Pulmonary arterial hypertension
  • QT interval prolongation (A heart rhythm disorder that can potentially cause fast, chaotic heartbeats). These include patients with hypokalemia or hypomagnesemia, patients with congenital long QT syndrome, patients taking anti-arrhythmic medicines or other medicinal products that lead to QT prolongation, and cumulative high-dose anthracycline therapy.
  •  problems with your immune system
  • Liver problems
  •  Heart problems 
  •  Lactose Intolerance.

Side-effects of Dasatinib

Below mentioned are some possible side effects by Dasatinib.  It is advised to consult your doctor immediately if any of such side effects are noticed.

  • Body aches or Pain
  • Burning, numbness, tingling in the arms and feet
  • Chest pain
  • Chills
  • Cough
  • Dizziness
  • Nausea
  • Headache
  • Weight gain
  • Fever
  • Irritation of throat
  • Ulcers or white spots in the mouth
  • Irregular breathing
  • Increased sweating

Effects on organs

Limited data is available about the effect of Dasatinib on body organs.

  • Bone marrow suppression
  • Bleeding related events
  • Fluid retention
  • Congestive Heart failure, left ventricular dysfunction, and myocardial infarction, QT prolongation.

 Administration of Dasatinib has the possibility of severe side effects in patients suffering from cardiac or blood vessel disorders and hepatic impairment. Consult your doctor immediately if symptoms like fever, chills or sore throat happen. It is advised to consult the doctor and share detailed information about your current health condition so that the doctor can alter the dosage depending on your health condition.

Reported Allergic Reactions?

No major allergic reactions are noticed in case of Dasatinib. But it is not recommended in patients who have known allergic reactions towards Dasatinib.

Effect on menstrual cycle

Limited clinical data is available regarding the effect of this medicine on menstrual cycle. You may consult your gynaecologist.

Drug Interactions to Be Careful About

Dasatinib may possibly show drug interaction with some other medication if they are used together. It is advised to share the medication details that you might be using any with your doctor before he prescribes this medicine to you.

Some of the drugs with which Dasatinib shows interaction include:

  • BCG vaccine
  • Adalimumab
  • Alteplase
  • Dabigatran
  • Cisapride
  • Diclofenac
  • Lasix
  • Pantoprazole
  • Topamax
  • Tylenol
  • Vitamin C, Vitamin B12.

Food interactions

Consumption of grapefruit or grapefruit juice is not advised as this may effect in the medicine levels in the blood and cause severe side effects such as nausea, vomiting, loss of appetite, mouth sores, diarrhea, hair loss, pain, numbness, weakness. Follow the guidelines mentioned in the prescription as a safety precaution.

Interactions with laboratory procedures

Hypophosphatemia, Hypokalemia, Hypocalcemia, Elevated SGPT (ALT), SGOT(AST), Elevated creatinine and bilirubin are reported. It is always good to share details about your current medication before attending any lab tests so that you doctor and lab technician is aware of.

Is Dasatinib Addictive?

No drug addiction is noticed in the case of Dasatinib.

Can I have Dasatinib with alcohol?

Limited data is available regarding the interaction of this medicine with alcohol. Consult with your doctor if you have a habit of regular intake of alcohol.

Can I have Dasatinib When Pregnant?

Not advised to use in general in pregnant women.

Can I have Dasatinib when feeding a baby?

Not advised to use in general in breastfeeding women.

Can I drive after taking Dasatinib?

Dasatinib may cause general weakness as a side effect in some patients. In such conditions, it is not advised to do activities such as driving which require alertness.

Effect of overdose Dasatinib

Severe Myelosuppresion and Cardiac Toxicity may be possible if overdosage happens in large quantities. Consult your doctor immediately in such situations.

Effect of using expired Dasatinib?

It is advised not to use any medicine that is expired to avoid any adverse effects. Consult your doctor immediately if any adverse effects are noticed by taking any expired medicine. It is advised to check the label while purchasing the medicine to verify the expiry date to be safe.

Effect of missing a dose of Dasatinib

No major adverse effects are noticed if only one dosage is missed. But if you are missing the dosages regularly, it is advised to keep a reminder so that you don’t miss the regular dosage.

Storage requirements for Dasatinib

Storage of this medicine requires refrigeration and away from direct sunlight. Keep away from the reach of the children and pets.

Available brands of Dasatinib

Below mentioned is the available brand of medicine that contains Dasatinib as key ingredient, and your doctor may prescribe this to treat the condition.

  • Sprycel Tablet  – manufactured by Bristol-Myers Squibb India Pvt Ltd
  • Dasanat Tablet – manufactured by Natco Pharma Ltd.

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