Ambisome

Ambisome

What is Ambisome?

Ambisome is an anti-fungal medication prescribed to treat several fungal infections and also to treat a kind parasitic infection disease called black fever or kala-azar. This medication is advised to use under medical supervision only. This medicine is available in injection form for intravenous purposes and is administered by medical professionals only.

Type of drug

Ambisome belongs to anti-fungal medication. This medicine is available in injection form and is used for intravenous administration.

Use in brief

Ambisome is prescribed to use in the treatment of several fungal infections and black fever.

Constituents

Ambisome Injection contains Amphotericin B (Liposomal) as an active ingredient.

Indications

Ambisome is prescribed in the treatment of several fungal infections and black fever which is also known as kala-azar.

Fungal infection such as

  • Invasive Aspergillosis
  • Candidemia
  • Cryptococcosis
  • Febrile Neutropenia
  • Cryptococcal Meningitis

Kala-azar or black fever

  • Leishmaniasis – a disease caused by an intracellular protozoan parasite transmitted by the bite of a female phlebotomine sandfly

How does Ambisome work?

Ambisome works by killing the fungi by destroying the fungal cell membrane.

How to Take Ambisome?

Form of medicine – Ambisome medicine is available in the form of injection for intravenous administration.

When and How to use

This medicine is given by your doctor or nurse but not for self-use. Follow the instructions as mentioned in the prescription.

Common Dosage            

The dosage depends on the severity of the health condition been treated and is decided by the doctor. Follow the instruction by your doctor. This medicine is administered by your doctor or nurse hence the chance of overdosing is very rare. Consult your doctor if you forget to get certain dosage schedule.

When to Avoid Ambisome?

Ambisome is not advised to use in some health conditions such as:

  • Allergic reaction towards the Ambisome medication
  • In case of Non-invasive fungal infections

Side-effects of Ambisome

Ambisome may possibly show some side effects in some patients. It is advised to consult your doctor if any of such side effects are noticed and if they are prolonged. Below mentioned are some possible side effects by Ambisome. It may show side effects that are not mentioned here in this list.

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhea
  • Upset stomach
  • Loss of appetite
  • Muscle or joint pain
  • Headache
  • Ringing in your ears
  • Pain, bruising or swelling at the site of injection
  • Weight loss
  • Flushing
  • Warmth
  • Redness
  • Tingly feeling
  • Irregular heartbeat
  • Decreased potassium levels
  • Anemia
  • Chest pain

Effects on organs

This medicine may possibly show adverse effects on the organs like liver, kidneys. The possibility of nephrotoxicity is higher with usage of this medicine. It is advised to take extreme precautions and medical supervision in case of severe health disorders or impairment related to these organs. It is advised to consult the doctor and share detailed information about the current health condition so that the doctor can alter the dosage depending on the patient’s health condition.

Reported Allergic Reactions?

  • It is not recommended in patients who have known allergic reactions towards Ambisome.
  • Severe adverse effects such as hypotension, hypokalemia, arrhythmias, and shock are possible if rapid intravenous infusion occurs.
  • Some patients may experience allergic reactions such as headache, fever, chills, loss of appetite, nausea, vomiting, breathing problems, or dizziness during initial doses which would most likely diminish with subsequent doses

Effect on the menstrual cycle

Generally, no effect noted on the menstrual cycle. You may consult your gynaecologist.

Drug Interactions to Be Careful About

Ambisome may possibly show drug interaction with some other medication if they are used together. It is advised to share the medication details that you might be using any with your doctor before he prescribes this medicine to you.

Ambisome has the possibility of showing drug interaction if used along with the below-mentioned list of medicine.

  • Tacrolimus
  • Cidofovir
  • Indapamide
  • Flucytosine

Food interactions

Limited clinical data is available on food interaction of this medicine. Consult your doctor for further information.

Interactions with laboratory procedures

There is no interaction noticed with any diagnostic test while under the medication but it is always good to share details about your current medication before attending any lab tests so that your doctor and lab technician is aware of.

Shows Effects / Results in and how long do the effect stay

Limited data is available regarding the onset of action and how long the effect stays. Consult your doctor if you are concerned about the onset of action and duration of effect.

Is Ambisome Addictive?

No drug addiction is noticed in case of Ambisome.

Can I have Ambisome with alcohol?

Limited data is available about the effect of Ambisome if consumed with alcohol. Consult your doctor if you have a habit of taking alcohol on regular basis.

Can I have Ambisome When Pregnant?

Not advised to use in general in pregnant women and it may show adverse effects on the fetus. But with consultation and supervision in case if unavoidable and the intended benefits are more compared to possible side effects.

Can I have Ambisome when feeding a baby?

Not advised to use in general in breastfeeding women. But with consultation and supervision in case if unavoidable and the intended benefits are more compared to possible side effects.

Can I drive after taking Ambisome?

This medicine is not known to cause any adverse effects like that may affect the ability to drive. But if you are feeling tired or weak as part of side effects, it is not advised to drive. 

Effect of overdose Ambisome

A chance of overdosing is very rare as this medicine is administered by qualified medical professionals only. Emergency precautions shall be taken if an overdosage happens.

Effect of using expired Ambisome?

It is advised not to use any medicine that is expired to avoid any adverse effects. Consult your doctor immediately if any adverse effects are noticed by taking any expired medicine. It is advised to check the label while purchasing the medicine to verify the expiry date to be safe.

Effect of missing a dose of Ambisome

This medicine is available in injection form and is administered in a hospital environment by trained medical professionals. If you forgot a dosage, consult your doctor immediately for further assistance.

Storage requirements

This medicine has to be stored in a refrigeration condition once it is reconstituted. Keep out of reach from direct sunlight, and out of reach from children and pets.

Alternate Brands of Ambisome medicine available

Below mentioned brands of medicine are with similar composition and strength, hence your doctor may prescribe any of these as an alternative option to treat your condition.

  • Phosome 50mg Injection – Manufactured by Cipla Ltd
  • Amphotret 50mg Injection and Amphonex 50 mg Injection – Manufactured by Bharat Serums & Vaccines Ltd
  • Amphotin Lip 50 mg Injection – Manufactured by United Biotech Pvt Ltd
  • Amfy 50 mg Injection – Manufactured by Intas Pharmaceuticals Ltd

If for some reason an experienced doctor is not available around you, then you can contact us here.

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