Allopurinol Uses, Side effects, Dosage

Allopurinol

Allopurinol belongs to a class of medication called xanthine oxidase inhibitors. It is widely used in treatment of kidney stones or gout.  Allopurinol tablets reduce the production of uric acid in your body. Uric acid buildup can lead to kidney stones or gout. Allopurinol tablets are used to treat kidney stones or gout, and to decrease levels of uric acid in patients who are receiving cancer treatment.

1. Allopurinol Uses
2. Allopurinol Side effects
3. Contraindications of Allopurinol
4. Allopurinol Dosage
5. Allopurinol Interactions

Allopurinol Uses

These tablets are used to decrease uric acid levels in the blood and urine of people with high uric acid levels. High uric acid levels may be caused by the following conditions:

Gouty arthritis

These tablets used in the treatment of gout or gouty arthritis which is a type of arthritis that causes chronic pain, redness, and tenderness in the joints.

Hyperuricemia Secondary to Chemotherapy

These tablets used to lower the uric acid levels in people who are receiving chemotherapy for cancer or for patients with kidney stones that contain calcium.

This drug may be prescribed for other uses. Ask your physician for more information.

Allopurinol Side effects

These may cause drowsiness (sleepiness). You shouldn’t drive, use machinery, or do other works that require alertness until you know how allopurinol affects you. It can also cause other side effects.

More common side effects

In addition to its intended benefits, Allopurinol may cause some unwanted effects too. In such cases, you must seek medical attention immediately. Please inform your doctor if you experience any adverse reaction to the medication.

The more common side effects of allopurinol can include:

  • Skin rash
  • Gout flare-up (if you have gout)
  • Diarrhea
  • Nausea
  • Headache
  • Muscle pain
  • Changes in your liver function test results
  • Depression
  • Loss of appetite
  • Change in taste
  • Blurred vision

Contraindications of Allopurinol

Who should not take Allopurinol?

Check with your doctor if you have any of the following Conditions:

Chronic Heart Failure, Extreme Loss of Body Water, Liver Problems, Allergic Reaction causing Inflammation of Blood Vessels, Moderate to Severe Kidney Impairment.

Allergies:

Allopurinol Analogues

Allopurinol Dosage

Adult dose of allopurinol for gout is:

Initial Dose: 100 to 200 mg (milligrams), once a day.

Maintenance Dose: 200 to 300 mg (milligrams) orally, once a day, for mild gout or 400 to 600 mg a day in divided doses for moderately severe gout.

To reduce the risk of kidney stones forming, you should drink 8 to 10 full glasses of water or fluid every day. Take each dose with a full glass of water.

Before taking allopurinol

You should not take allopurinol if you are allergic to it. To make sure you can safely take allopurinol, tell your doctor if you have any of these other conditions:

  • Kidney disease
  • Congestive heart failure
  • Diabetes
  • High blood pressure
  • Liver disease
  • If you are receiving any chemotherapy

Overdosage

Taking more than prescribed allopurinol may cause harmful side effects. Consult your physician or pharmacist if you find any side effects.

Missing dosage

If you miss the dosage take as soon as possible, and if it is near to next dose, skip the missing dosage continue the regular dosage. Do not take extra doses.

Pregnancy

Allopurinol not recommended for use in pregnant women unless necessary and the potential benefits outweigh the risks involved. Allopurinol not known to cause any harm to the fetus, but should only be used after consultation with your physician.

Breastfeeding

This drug can pass into breast milk and may harm a nursing baby. Do not use this drug without telling your doctor if you are breast-feeding a baby.

Allopurinol Interactions

If you use other over the counter products or other drugs at the same time, the effects of the Allopurinol may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your physician about all the medicines you take including prescription and non-prescription medicines, herbal supplements, and vitamins. Especially tell your physician if you take:

  • An ACE inhibitor
  • A diuretic (thiazides)
  • Ampicillin (Omnipen, Principen, Polycillin)
  • Cyclophosphamide (Cytoxan)
  • Blood thinners such as warfarin (Coumadin, Jantoven)
  • Chlorpropamide (Diabinese)
  • Mercaptopurine (Purinethol)
  • Cyclosporine (Neoral, Sandimmune)
  • Didanosine (Videx, Videx EC)
  • Azathioprine (Imuran)
  • Probenecid (Benemid)
  • Sulfinpyrazone (Anturane)
  • Amoxicillin (Amoxil, Trimox)

This is not a complete list of allopurinol drug interactions. Ask your physician for more information.

If for some reason an experienced doctor is not available around you, then you can contact us here.

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