Aceclofenac and its Uses & Side Effects

Aceclofenac – Composition, Uses, Side-Effects, Substitutes, Warnings

Everything you wanted to know about it

Anti-inflammatories like Aceclofenac are also called non-steroidal anti-inflammatory drugs(NSAIDs), or sometimes just Anti-inflammatory painkillers. Aceclofenac is prescribed for people with painful arthritic conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Get to know how Aceclofenac works, its side effects, precautions, and contraindications where Aceclofenac is not suggested.

Read about Aceclofenac in Hindi

Aceclofenac  – Mechanism Of Action

It reduces pain and eases inflammation. Aceclofenac available in the tablet form and administered orally. This is a class of medications that are not Steroidal, but still reduce inflammation in the body, like Ibuprofen, Naproxen, or Aspirin. They were named this simply to identify them as anti-inflammatory drugs that did not fit in the steroid class. Steroids, like dexamethasone and prednisone, were the originally discovered medications that fought inflammation in the body, but have many dangerous side effects.

Aceclofenac works by blocking the effect of natural substances called Cyclooxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins.

It works by blocking the release of certain chemical messengers that cause fever, pain, and inflammation.

Read about some similar painkiller medicines

Hifenac Tablets
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Mitigate Tablets

Prescribed in following conditions

It is indicated for the:

  1. Relief of mild to moderate acute pain.
  2. Pain and Inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.


Used to treat symptoms like joint stiffness, painful joints of the knee, hip, neck, lower back associated with Osteoarthritis.

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Rheumatoid Arthritis

Used to treat symptoms like joint stiffness, pain, and swelling associated with Rheumatoid Arthritis.

Ankylosing Spondylitis

Used to treat symptoms of  Ankylosing Spondylitis such as spinal stiffness and pain.

It is also used in:

  • Fever
  • Dental pain
  • Headache
  • Post-operative pain

Contraindicated in following conditions:


Avoid if you have allergy to Aceclofenac or other NSAIDs


Aceclofenac is not contraindicated if you are diagnosed with asthma or other respiratory complications.


If you are suffering from any bleeding disorder Aceclofenac is not recommended for you. It could cause severe swelling and bleeding in the intestines, stomach, and anus.

Warnings and precautions

  1. If you pass stool in black or blood consult your doctor
  2. Do not take if you are allergic to aceclofenac
  3. The Aceclofenac’s effect may last 8-12 hours
  4. It is not fully safe to take while pregnant and breastfeeding
  5. Keep these medicine stay out of children
  6. If you experience drowsiness, dizziness, you must not drive or use machinery
  7. If your doctor prescribes aceclofenac medicine, tell your doctor all the medicines you are using for heart, kidney, asthma and gastric problems
  8. Should not be given to the people who are suffering from porphyria (A group of disorders that affecting the nervous system, skin and other organs)
  9. Swallow the tablet whole with a glass of water. Do not crush or chew the tablets.

Aceclofenac side effects

In addition to its intended effect, Aceclofenac may cause some unwanted effects too. If you experience any of the following side effects consult your doctor immediately.

  • Skin Rash
  • Abdominal Pain
  • Constipation
  • Vomiting
  • Dizziness
  • Nausea and vomiting
  • Diarrhea

Adverse reactions

  • Cardiovascular Thrombotic Events
  • GI Bleeding, Ulceration and Perforation
  •  Hepatotoxicity
  •  Hypertension
  •  Heart Failure and Edema
  •  Renal Toxicity and Hyperkalemia
  •  Anaphylactic Reactions
  •  Serious Skin Reactions
  • Hematologic Toxicity

Drug Interactions:

  • Aspirin: Concomitant use of NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to the use of the NSAID alone
  • Warfarin
  • Digoxin
  • Lithium
  • Diuretics
  • Methotrexate
  • Cyclosporin
  • Nsaids and Salicylates
  • ACE inhibitors

Laboratory monitoring

Because serious GI bleeding, hepatotoxicity, and renal injury can occur without warning, symptoms or signs, consider monitoring patients on long-term NSAID treatment with a CBC and a chemistry profile periodically.


Aceclofenac is available as 100mg tablets,200mg tablets. The Aceclofenac tablet is usually prescribed twice in a day, commonly in the morning and evening. It can be taken with food or after food. Drinking an adequate amount of water minimizes chances of indigestion and stomach irritation.


Taking more than prescribed may cause harmful side effects. Consult your doctor or pharmacist if you find any side effects.

Missing dosage

If you miss the dosage take as soon as possible, and if it is near to next dose, skip the missing dosage continue the regular dosage. Do not take extra doses.

Substitutes for Aceclofenac Tablet

Below is the list of medicines, which have the same composition, action, and form as Aceclofenac Tablet, and hence can be used as its substitutes:

  • Hifenac
  • Zerodol
  • Dolowin
  • Aceclo
  • Arflur
  • Movon
  • Acenac
  • Topnac
  • Safronac
  • Akilos

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Aceclofenac - Composition, Uses, Side-Effects, Substitutes, Warnings
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