What is Abiraterone Acetate?
Abiraterone Acetate is an anti-cancer medication prescribed to treat prostate cancer that has spread to other parts of the body. This medicine prescribed as a combination medicine along with another drug called prednisone. This medication is advised to use under medical supervision only and advised to use in patients in whom there is no response towards other treatment options.
Type of drug
Abiraterone Acetate belongs to anti-androgens (anti-testosterone) group of drugs.
Use in brief
Abiraterone Acetate is prescribed in the treatment of prostate cancer.
Abiraterone is an active ingredient in several branded drugs like Abiraterone acetate, Zytiga, Yonsa, and others. Abiraterone is a derivative of steroidal progesterone. Abiraterone is administered as an acetate salt prodrug.
Abiraterone acetate (Zytiga®) is a type of hormone therapy for men with prostate cancer that has spread to other parts of the body (advanced prostate cancer) and has stopped responding to other types of hormone therapy. Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.
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How does Abiraterone Acetate work?
Works by inhibiting an enzyme called CYP17A1 which is responsible for producing hormone called androgen (male hormone).
How to Take Abiraterone Acetate?
Form of medicine – Abiraterone Acetate medicine is available in the form of tablets.
When and How to use?
Follow the instructions as mentioned in the prescription. This medicine is advised to use with an empty stomach. Never crush or chew the tablets but swallow the whole medicine along with some water or liquids. Taking abiraterone with food greatly increases the amount of this drug in your body and increases the risk of side effects.
It is available as 250mg and 500mg tablets. Dosage depends on the severity of the health condition been treated and is decided by the doctor. Never miss a dose or take excess dose. Consult your doctor immediately if any excess dosage happens by mistake.
When to Avoid Abiraterone Acetate?
Abiraterone Acetate is not advised to use in some health conditions such as:
- Allergic reaction towards the Abiraterone Acetate medication
- Not recommended in women
- Not recommended in children.
Side-effects of Abiraterone Acetate:
Abiraterone Acetate may possibly show some side effects in some patients. It is advised to consult your doctor if any of such side effects are noticed and if they are prolonged. Below mentioned are some possible side effects by Abiraterone Acetate. It may show side effects that are not mentioned here in this list.
- Decreased potassium level in blood
- Edema (swelling)
- Decreased white blood cell count
- Increased liver enzymes
- Anemia (low number of red blood cells)
- Urinary tract infection
- High blood pressure
- Increased cholesterol level in blood
- Hot flashes
- Joint swelling
- Increased levels of blood fat
- Altered blood sugar level
- Taking abiraterone may cause your bones to get thinner and weaker over time. You can help keep your bones strong and reduce your risk of severe bone thinning (osteoporosis) by making changes to your lifestyle. If you already have osteoporosis, your doctor may suggest taking medicines, such as bisphosphonates, to help reduce the risk of broken bones.
Effects on organs:
This medicine may possibly show adverse effects on the organs like heart, liver.
Heart: It affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat.
Liver: This drug causes liver toxicity. It is necessary to monitor AST and ALT levels during the treatment.
It is advised to consult the doctor and share detailed information about the current health condition so that the doctor can alter the dosage depending on the patient’s health condition.
Reported Allergic Reactions?
It is not recommended in patients who have known allergic reactions towards Abiraterone Acetate.
Effect on menstrual cycle
This medicine is generally not prescribed for women.
Drug Interactions to Be Careful About:
Abiraterone Acetate has the possibility of showing drug interaction if used along with the below-mentioned list of medicine. It is advised to share the medication details that you might be using any with your doctor before he prescribes this medicine to you.
This medicine is advised to take without food as consumption along with food may trigger complications like high blood pressure, muscle weakness, breathing difficulties and paralysis. It is advised to maintain a gap of at least 1 hour before and 2 hours after taking this medicine.
Interactions with laboratory procedures:
Limited data is available on interaction with any diagnostic test while under the medication but it is always good to share details about your current medication before attending any lab tests so that you doctor and lab technician is aware of.
Is Abiraterone Acetate Addictive?
No drug addiction is noticed in case of Abiraterone Acetate.
Can I have Abiraterone Acetate with alcohol?
Limited data is available about the effect of Abiraterone Acetate if consumed with alcohol. Consult your doctor if you have a habit of taking alcohol at a regular basis.
Can I have Abiraterone Acetate When Pregnant?
This medicine is not prescribed for women.
Can I have Abiraterone Acetate when feeding a baby?
This medicine is not prescribed for women.
Can I drive after taking Abiraterone Acetate?
This medicine is not known to cause any adverse effects like that may affect ability to drive. But if you feel like tired as part of side effects, it is not advised to drive.
Effect of overdose Abiraterone Acetate
Serious adverse effects may be possible if overdosage happens in large quantities. Consult your doctor immediately in such situations.
Effect of using expired Abiraterone Acetate?
It is advised not to use any medicine that is expired to avoid any adverse effects. Consult your doctor immediately if any adverse effects are noticed by taking any expired medicine. It is advised to check the label while purchasing the medicine to verify the expiry date to be safe.
Effect of missing a dose of Abiraterone Acetate
No major adverse effects are noticed if only one dosage is missed. But if you are missing the dosages regularly, it is advised to keep a reminder so that you don’t miss the regular dosage.
It is advised to store the medication away from direct sunlight and to keep at room temperature. Keep away from the reach of the children and pets.
Different Brands of Abiraterone Acetate medicine available
Below mentioned is the available brand of medicine that contains Abiraterone Acetate as key ingredient, and your doctor may prescribe this to treat the condition.
- Abirapro 250 mg Tablet – Manufactured by Glenmark Pharmaceuticals Ltd
- Xbira 250mg Tablet – Manufactured by Cipla Ltd
- Zecyte 250mg Tablet – Manufactured by Cipla Ltd
- Zybirra Tablet – Manufactured by Zydus Cadila
- Arbitus Tablet – Manufactured by Dr Reddy’s Laboratories Ltd
- Abiracure Tablet – Manufactured by Emcure Pharmaceuticals Ltd.
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Dr. Divya has been pursuing Dentistry for about 5 years now. Endodontics and Orthodontics are her areas of interest and she holds a BDS degree from Govt. Dental College, Vijayawada, AP. Besides pursuing her career as a Dentist, she is passionate about Technical writing and is spending her free time in writing medical articles to bring awareness and share medical knowledge to the public.